Presentations, Publications & White Papers
Leap-In Transposase Platform – The power of the pool
Leap-In Transposase Platform - The power of the pool
2023, European Bispecific & Multispecific Antibody Congress, Amsterdam, The Netherlands
Oren Beske, Ph.D
Leap In Transposase Platform – It’s what you paste
Leap-In Transposase Platform - It's what you paste...
2022, Festival of Biologics, Basel, Switzerland
Oren Beske, Ph.D
The GPS Platform
The GPS Platform
2022, Festival of Biologics, Basel, Switzerland
Oren Beske, Ph.D
Leap-In Transposase Platform – How’s it going? Where we are going…
Leap-In Transposase Platform - How's it going? Where we are going...
2021, Antibody Engineering & Therapeutics, San Diego
Oren Beske, Ph.D
Leap-In Transposase Platform – From shiny and new to tried and true
Leap-In Transposase -
From shiny and new to tried and true
2021, PEGS Europe, Barcelona
Oren Beske, Ph.D
Cell Line Development for Multi chain Biologics: Leveraging the Leap-In Transposase Platform
Cell Line Development for Multi chain Biologics: Leveraging the Leap-In Transposase Platform
2021, PEGS Europe, Barcelona
Oren Beske, Ph.D
Antibody Production - Fast and Furious at a Pandemic Response Pace
2020, Antibody Engineering & Therapeutics
Oren Beske, Ph.D
Navigating Infinite Sequence-Function Space in Proteins
2020, Antibody Engineering & Therapeutics
Claes Gustafsson, Ph.D
2024 February
Cancers 2024
2024 February
Biotechnology and Bioengineering
Biotechnology and Bioengineering
2019 September
GenEng News
2018 October
Biotechnology Journal
2018 September
Current Protocols in Protein Science
2024 February
Directed evolution is a method for engineering proteins that involves mimicking natural selection in a laboratory setting. We interviewed experts from several companies to understand where this approach—which originated in the 1960s—is heading.
Tiffany Yesavage, Ph.D.
2023 August
Leap-In Transposase platform, main rationale behind SBCs and some key points to consider when evaluating a development pathway leveraging the speed of an SBC-based platform.
Protein Engineering Solutions
Protein Engineering Solutions
No surrogate assays, no compromises. Scaled for industrial success. Achieve your goals efficiently.
Rapid, Scarless Cloning of Gene Fragments Using the Electra Vector System™
Rapid, Scarless Cloning of Gene Fragments Using the Electra Vector System™
Laura Whitman, Medini Gore, Jon Ness Ph.D., Elias Theodorou, Ph.D., Claes Gustafsson, Ph.D., and Jeremy Minshull, Ph.D.
Library Format for Bioengineering. Maximizing Screening Efficiency through Good Design.
Library Format for Bioengineering. Maximizing Screening Efficiency through Good Design.
Maximizing screening efficiency through good design.
ATUM Pfenex Boehringer Ingelheim Collaboration Case Study/White Paper
ATUM Pfenex Boehringer Ingelheim Collaboration Case Study/White Paper
Strategic partnerships can offer great advantages for the time-to-clinic development of difficult-to-express proteins.
Xmas message from Extraterrestrial Intelligence Found in Transposon Encoded DNA.
Xmas message from Extraterrestrial Intelligence Found in Transposon Encoded DNA.
Proc Natl Acad Sci Northpole 2018. 12:25-31.
ATUM elves decode Xmas message found in Leap-In like transposon.
Gain-of-function applications of Festive Fluorescent Proteins enabled through development of CHO-HO-HO cell line.
Gain-of-function applications of Festive Fluorescent Proteins enabled through development of CHO-HO-HO cell line.
Proc Natl Acad Sci Northpole 2017. 12:25-31.
ATUM elves identify a novel class of protein Christmaspiritin that stimulates engineered CHO cells expressing FFPs into highly complex jolly patterns.
Optimization of Eggnog using Design of Experiment and Machine Learning
Optimization of Eggnog using Design of Experiment and Machine Learning.
Proc Natl Acad Sci Northpole 2015. 12:25-31
ATUM elves use DoE to optimize Mrs. Claus’ eggnog recipe.
KRISPR-KRINGLEi Utilized for Leptin Supression in Elves (Denisova hominin)
KRISPR-KRINGLEi Utilized for Leptin Supression in Elves (Denisova hominin).
Proc Natl Acad Sci Northpole 2013. 12:25-31.
ATUM elves utilize the CRISPR system to improve Elf health.
Deconvolution of Inherent Genomic-Melodic Linkages, or The Music of Life.
Deconvolution of Inherent Genomic-Melodic Linkages, or The Music of Life
Proc Natl Acad Sci Northpole 2012. 12:25-31.
ATUM elves utilize the CRISPR system to improve Elf health.
Nine improved monomeric fluorescent proteins from Rangifer tarandus
Nine improved monomeric fluorescent proteins from Rangifer tarandus
Proc Natl Acad Sci Northpole 2011. 12:25-31.
ATUM elves used whole genome sequencing and genome-wide functional association studies to identify the red fluorescent protein, Rudolph. Directed evolution and protein engineering (ProteinGPS) further identified eight additional colors. The reindeer proteins are in the public domain and sold under the BioBrick Public Agreement.
Carolome: Functional Imprints of Culture Memes in Global Genome
Carolome: Functional Imprints of Culture Memes in Global Genome
Proc Natl Acad Sci Northpole 2010. 12:25-31.
ATUM elves have systematically identified Christmas carols deposited in sequence data, and established their direct role in the functional imprint and transfer of genetic information. They name this exciting new field of research Carolomics.
For anyone who ever said there’s no such thing as a poetic gene.
For anyone who ever said there's no such thing as a poetic gene
Nature 2009. 458:703.
Correspondence to Nature regarding poetry in synthetic genomes.
Metabolic engineering of Picea abies for receptor mediated induction of fluorescence and olfactory signaling
Metabolic engineering of Picea abies for receptor mediated induction of fluorescence and olfactory signaling
Proc Natl Acad Sci Northpole 2008 12:25-31.
In a concerted synthetic biology and tissue engineering effort, a team lead by Santa Claes at the Univ Northpole designed and constructed a christmas tree that induced endogenous fluorescent sparkling and olfactory emission after induction by christmas carols.
Heterologous expression and functional characterization of the Santa Hoho2 gene
Heterologous expression and functional characterization of the Santa Hoho2 gene
Proc Natl Acad Sci Northpole 2006. 12:25
The Hoho2 gene responsible for facial hair formation of Santa Claus is isolated and shown to be an ortholog of human KRT6B. The Hoho2 gene was codon optimized and and the corresponding protein expressed in E. coli, reindeer and human. RNAi knockout constructs could be trans-complemented with an RNAi resistant Hoho2 variant. Brilliant science by Prof Elf and coworkers at Univ Northpole.
Creation of the Tomten Gene G051225
Creation of the Tomten Gene G051225
Int Pub 2005 12:25
In an attempt to honor Tomten and investigate its molecular basis, ATUM created the Tomten gene. The gene was codon optimized for expression in Reindeer, synthesized and cloned. Constructs successfully expressed the glowing snow of the Tomten.